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Rubinstein-Taybi Syndrome (RTS or RSTS) is a genetic condition caused in part by changes in genes, or changes on chromosome 16. Individuals with RTS typically have short stature, moderate to significant developmental delay, distinctive facial features, and broad thumbs and first toes. People with RTS usually have an intellectual disability. There is great variation in physical characteristics, medical problems, and intellectual abilities. About 1 in 100,000 to 125,000 newborns have RTS.