Risk of most cancer types are determined by a complex interplay of genetic and environmental factors. Recent studies provide theoretical and empirical evidence that additional genetic and environmental factors can be identified in studies that examine gene-environment (GxE) interactions. More importantly, GxE interaction research has the potential to facilitate insights into biological mechanisms and strategies for cancer prevention and control. Despite progress, several challenges remain for performing these studies. These challenges stem, in part, from the complex, evolving, and expanding nature of the genetic and environmental data collected.
The Epidemiology and Genomics Research Program (EGRP), at the National Cancer Institute's (NCI) Division of Cancer Control and Population Sciences (DCCPS), supports extramural research that investigates both genetic and environmental factors that may contribute to the etiology of cancer and/or impact cancer outcomes. Read more.